Manchester, Otter, Liverpool Lizards and Coventry are already through. And Leeds and Sheffield both maintained their challenge with vital wins on day one.
Leeds cruised to a 13-3 victory over Coventry, including six goals by Nilacala Ward and two apiece for Molly Quinn, Candyce Schroeder and Hannah Pritchett. Sheffield's match with Caledonia was much closer; Sharks let slip a 12-10 lead in the last period as Caledonia levelled at 12-12 but then claimed the winner 47 seconds from the final hooter thanks to Bernice Cowton.
Manchester lost for the first time this season - 9-8 to Otter. The London side were narrowly ahead for much of the game but saw an 8-6 advantage late on cut back to 8-8 before a Danica Brazier goal secured the win.