But of course all it not lost for the Lizards. A single point from the remaining phase one matches should be sufficient to clinch a place in the Super 5s, earning a welcome fresh start in the New Year.
The same applies to current champions Otter, beaten 13-11 by City of Coventry in a match the London side led at 4-2 and 6-5 before conceding defeat late on. There were Coventry hat-tricks by Rhianne Oscroft and Kimberly Watson.
Coventry and Manchester now head for the final weekend of competition at the new BWPL venue of Manchester's Jason Kenny Centre (1/2 December) with perfect records from five matches. They meet on the final day.
Sheffield Sharks won for the first time - 15-12 against Hucknall. It was by no means straightforward. Hucknall led 6-3 midway through the second period and, briefly, were only 11-10 adrift at the start of the last. Bernice Cowton (4) and Danielle Elliot (4) provided the bulk of the Sheffield goals. Caledonia beat Leeds Sharks 10-8 to notch a second win, with Hannah Edwards' five goals providing the highlight.