The game was effectively all over before the end of the second period when Manchester's runaway start had built a 7-0 lead thanks to goals by Harriet Dickens (2), Brooke Tafazolli (2), Izzy Howe, Isabelle Robb and Lucy Blenkinship.
To their credit, Liverpool battled back to reduce the Manchester advantage to 8-5. But, despite some excellent saves by Liverpool goalkeeper Hayley Price, Manchester eased clear in the final stages to win 14-8.
The trophy and medals were presented by BWPL President Trevor Pledger, assisted by Ian Mackenzie, Chairman, Swim England Water Polo Leadership Group.
Earlier, Coventry beat Sheffield Sharks 12-7, ensuring their qualification for the Champions Cup, also to be staged at the Alan Higgs Centre, in May. The sides were level at 4-4 early in the second period before Coventry eased into a 9-5 lead at the end of the third with goals by Mathilde Ribordy (3), Sophie Linney and Rhianne Oscroft.
In the men's Super 5s, Dan Laxton took his goals tally for the Super 5s to 35 with seven more in Welsh Wanderers' 17-9 victory over Cheltenham.