Liverpool Lizards need just a point from remaining matches against Manchester and Coventry to secure the women's title for the first time.
But the men's competition could see Cheltenham and Lancaster going head-to-head for the championship in the very last match of the campaign.
Cheltenham begin the weekend with a single-point advantage over their great rivals. All will depend on how the sides fare on day one, when Cheltenham face Bristol and Lancaster play Manchester. See the fixtures and results pages for all the details.